Mezym (pancrelipase) is a combination of three enzymes (proteins): lipase, protease, and amylase. These enzymes are normally produced by the pancreas and are important in the digestion of fats, proteins, and sugars.
Mezym is used to replace these enzymes when the body does not have enough of its own. Certain medical conditions can cause this lack of enzymes, including cystic fibrosis, chronic inflammation of the pancreas, or blockage of the pancreatic ducts.
Mezym may also be used following surgical removal of the pancreas.
Mezym may also be used for purposes not listed in this medication guide.
Pancreatic enzyme supplements commonly cause gastrointestinal adverse effects such as abdominal discomfort and nausea and vomiting. They may also cause buccal and perianal irritation, particularly in infants. Colonic strictures (fibrosing colonopathy) have occurred, mainly in children with cystic fibrosis receiving high doses of Mezym preparations; the use of high doses in patients with cystic fibrosis should preferably be avoided. Adequate hydration should be maintained at all times in patients receiving higher strength preparations.
HOW SHOULD I USE MEZYM?
Use Mezym as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Mezym comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Mezym refilled.
Take Mezym by mouth with each meal or snack as directed by your doctor.
Swallow Mezym whole with enough liquid to swallow it completely. Do not break, crush, chew, or hold Mezym in your mouth before swallowing. Doing so may increase the risk of mouth irritation from Mezym. Follow with a glass of water or juice. Contact your doctor if you experience mouth irritation while taking Mezym.
If the patient is an infant (up to 12 months old), open the capsule and sprinkle the contents into the infant's mouth or over a small amount of applesauce at room temperature. Do NOT mix Mezym directly in breast milk or formula. If sprinkled onto applesauce, give the mixture to the infant right away. After giving Mezym, follow it with breast milk or formula. Be sure that none of the medicine is crushed, chewed, or left in the mouth.
If the patient is an adult or child older than 12 months old who cannot swallow the capsule whole, open it and sprinkle the contents over a small amount of acidic soft food (such as applesauce) at room temperature. Mix the medicine with the food and swallow the entire mixture right away, followed by a glass of water or juice. Be sure that none of the medicine is crushed, chewed, or left in the mouth. Check with your doctor if you are unsure which foods you may mix with Mezym.
If you miss a dose of Mezym, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once or take a dose without a snack or a meal.